CORDIS Project
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This project investigates how the epigenome is replicated during cell division, particularly in germline development. It aims to develop new technologies to track epigenetic changes in live organisms, providing insights into inheritance and cell identity.
Replication in S phase duplicates not only the genome but also the epigenome, to ensure cell identity is propagated and genome stability maintained in daughter cells.
Epigenome propagation in development has been understudied due to lack of appropriate methods, even though replication is widely accepted to be a primary vehicle through which programmed epigenetic changes occur in vivo.
In mammalian germline development, the epigenome is reprogrammed via impairment of the epigenome maintenance net…
KOBENHAVNS UNIVERSITET
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