CORDIS Project
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This project investigates the cellular mechanisms that maintain protein quality and prevent aggregation, which is crucial for cellular health. It aims to map the recognition systems that identify misfolded proteins and explore the roles of specific proteins in these pathways.
Proteostasis is a highly regulated process by which cells maintain a healthy proteome.
Loss of proteostasis is a common feature of aging and disease.
To preserve proteostasis, the cell has developed protein quality control (PQC) pathways that monitor a proteins’s fate from synthesis to degradation.
Exposed hydrophobic residues in aberrant or mislocalized protein substrates is a key feature recognized by distinct PQC mechanisms.
If not handled properly, exposed hydrophobicity can result in protei…
BAR ILAN UNIVERSITY
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