CORDIS Project
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This project aims to engineer the skin bacterium C. acnes to act as a therapeutic device for atopic dermatitis. By detecting inflammatory markers and producing anti-inflammatory molecules, it seeks to maintain skin health and provide new treatment options for patients.
The skin microbiome constitutes an attractive platform to incorporate novel functionalities to the host, due to accessible location, tight contact with the host, low immunogenicity, and easier genetic manipulation, among other reasons. I will adopt a translational synthetic biology approach to engineer the human skin commensal C. acnes (formerly P. acnes) as a disease-sensing biological device (“biodevice”) with therapeutic activity.
Precisely, engineered C. acnes will detect atopic dermatitis (…
UNIVERSIDAD POMPEU FABRA
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