CORDIS Project
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This project uses zebrafish to model Huntington's disease, focusing on the behavior of the huntingtin protein and its role in neurodegeneration. It aims to develop new therapeutic strategies by studying protein dynamics and neuroinflammatory responses.
Huntington´s disease (HD) is one of the nine neurodegenerative diseases (ND) caused by (CAG)n trinucleotide tract expansions that encode abnormally long polyglutamine (polyQ) tracts.
The common features shared by many ND are the misfolding and aggregation of toxic proteins.
Thus, HD recapitulates features of other, more complicated ND.
As HD is an autosomal dominant disorder, modeling this disease in vitro and in vivo is straightforward.
Unfortunately, HD is, to date, incurable and there are no…
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