CORDIS Project
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This project investigates the mechanisms of genetic mutations using computational analyses of human and mammalian genomes. By examining mutation rates and patterns, particularly in cancerous samples, it aims to enhance our understanding of mutagenesis and its implications for evolution and disease.
Mutations are the source of genetic variation in natural populations, provide material for molecular evolution and, importantly, cause human genetic diseases.
Yet the mechanisms of mutagenesis are, to date, not completely understood.
Low mutation frequencies limit direct observations in wet-lab experiments.
However, hundreds of resequenced human genomes (including cancerous samples) and hundreds of completely sequenced genomes of other species are accumulating at a growing pace.
Thus, bioinforma…
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