CORDIS Project
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This project investigates the structure and dynamics of the human CPEB3 ribozyme, an RNA enzyme linked to the Hepatitis Delta Virus. It aims to understand how metal ions influence its function, using techniques like nuclear magnetic resonance and single-molecule Förster Resonance Energy Transfer.
Until recently, ribozymes (enzymes composed of folded RNA) were found only in lower organisms.
The discovery of the human CPEB3 ribozyme, related to the Hepatitis Delta Virus one, was an enormous breakthrough, which gave rise to numerous scientific questions.In the scope of this project, I want to answer the most emerging ones;
I aim to solve the NMR structure of the whole CPEB3 ribozyme (we already have some promising preliminary results), as well as to crystallize it (in collaboration with ano…
University of Zurich
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