CORDIS Project
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This project investigates how the human placenta develops and its interaction with the maternal uterine environment. By utilizing advanced 3D organoid cultures and genome editing, it aims to uncover the cellular and molecular mechanisms that regulate placental growth and maternal-fetal interactions, which are critical…
How does the human placenta develop and how is this influenced by the maternal uterine microenvironment?
These are the central questions addressed in my proposal.
Normal growth and development of the fetus depends on the placenta, the extra-embryonic organ derived from trophectoderm.
Successful pregnancy depends on the earliest stages of development when placental extravillous trophoblast cells (EVT) infiltrate the uterine mucosa, the decidua. EVT invade the decidua to transform the uterine spir…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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