CORDIS Project
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This project investigates the role of specialized neurons in human cognition, focusing on the interactions between pyramidal neurons and double bouquet cells. By employing advanced techniques on human brain tissue, it aims to uncover the mechanisms underlying cognitive functions and potential therapeutic targets.
Human cognition stands out from other species, but how neurons and circuits in the human brain support cognition is poorly understood.
Our recent work showed that human brain holds specialized neuron types – pyramidal neurons in cortical layer 3 (L3 PNs) – with distinct properties that associate with IQ scores.
In the human brain, L3 PNs form circuits with each other and another human-specialized interneuron type, double bouquet cell (DBC).
These circuits might be critical for human cognition as…
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