CORDIS Project
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The HUMAN project aims to create mouse models with human liver and pancreatic cells to study genetic variants linked to metabolic diseases. By using cells from individuals with extreme health conditions, the project seeks to understand the impact of these variants on disease mechanisms and aging.
Recently intense research identified around 4,000 single nucleotide polymorphisms (SNPs) associated with human age related diseases such as metabolic disorders.
Despite their highly significant association to pathology, the functional role of these genetic variants is, in most cases, yet to be elucidated.
The evolutionary distance of most animal models from humans represents a major limitation for the functional validation of these SNPs.
To overcome these difficulties, HUMAN will generate mouse…
KAROLINSKA INSTITUTET
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Italy, Milano
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Leiden University Medical Center
Netherlands, Leiden
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
United Kingdom, London
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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