CORDIS Project
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This project investigates the structure and function of human telomerase RNA, a key component in maintaining chromosome stability. By using X-ray crystallography, it aims to reveal how telomerase operates and its potential implications for cancer treatment.
Telomeres are repetitive nucleotide sequences rich in guanine residues located at the termini of linear chromosomes of eukaryotic organisms.
Telomeres function as capping agents to protect chromosomes both from shortening at each replication cycle and from fusing with other chromosome ends or rearranging.
Maintenance of telomeres length is critical for genomic stability and cell viability.
Telomeres are consumed during cell division but can be replenished by telomerase, a unique ribonucleoprotei…
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