CORDIS Project
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This project investigates the role of serotonin receptors in Parkinson's Disease, focusing on their impact on motor symptoms and depression. By manipulating receptor activity in animal models, it aims to enhance understanding and treatment options for these interconnected symptoms.
Parkinson’s Disease (PD) is caused by dopaminergic neuron loss resulting in motor symptoms that are treated with L-DOPA.However, ≤90% of patients develop involuntary movements, termed L-DOPA induced dyskinesia (LID).
Another less well studied, buthighly occurring PD symptom is depression.There is evidence that the serotonin system is implicated in both, LID and PD-linked depression.
Serotonergic (5-HT) neuronsuncontrollably release L-DOPA-derived dopamine, and HTR1a/b agonists counteract such re…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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