CORDIS Project
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This project investigates the replication mechanism of the herpes simplex virus type 1 (HSV-1) genome using advanced single molecule imaging techniques. It aims to clarify the role of the UL9 protein in transitioning between different replication phases, focusing on its inhibitory effects during the origin-independent…
Herpes simplex virus type 1 (HSV-1) is a widespread and well-known pathogen.
However, we still lack a complete understanding of the mechanism of HSV-1 genome replication.
We propose to revisit long-standing questions of the HSV-1 genome replication mechanism using cutting-edge single molecule imaging techniques.
This approach enables the detection of transient structures and heterogeneous behavior, leading to further crucial insights into this fundamental process.
The current model for HSV-1 gen…
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