CORDIS Project
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This project investigates the interaction between the neuropeptide Big Dynorphin and the ASIC1a ion channel in the brain, which is linked to various neurological disorders. By using advanced electrophysiology techniques, the goal is to identify binding sites and interactions to aid in the development of targeted treatm…
Under physiological conditions, localized acidification of brain tissue serves as neuronal signal that get synaptically transduced via acid-sensing ion channels (ASIC1a).
Local acidosis has, however, also been linked to some of the most prevalent neurological disorders such as chronic pain, ischemic stroke and psychiatric diseases. ASIC1a has thus emerged as drug target with great potential, but no drugs are currently available that specifically target the channels under pathological conditions.…
KOBENHAVNS UNIVERSITET
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