CORDIS Project
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This project investigates the role of heat shock protein 90 and its co-chaperones in the virulence of Candida albicans, a common fungal pathogen. By exploring the genetic mechanisms that influence virulence, the research aims to identify new drug targets to combat infections, particularly in immunocompromised patients.
Most women will suffer at least one Candida albicans infection in their life.
While the majority of infections are not life-threatening, 50% of systemic infections in immunocompromised patients are lethal.
Treating C. albicans is challenging due to the close association with its human host, paucity of drug targets and drug resistances.
The conserved essential heat shock protein 90 (Hsp90) governs virulence, morphogenesis and drug resistance in C. albicans.
Yet, Hsp90 inhibition during mouse cand…
UNIVERSITY OF BATH
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