CORDIS Project
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This research investigates the genetic causes of childhood herpes simplex encephalitis, focusing on immune response deficiencies linked to specific gene mutations. It aims to identify additional genetic factors contributing to the disease and understand the cellular mechanisms involved.
Childhood herpes simplex encephalitis (HSE) is a potentially life-threatening complication of primary infection by herpes simplex virus-1 (HSV-1), a common virus that is innocuous in most children. HSE is the most common sporadic viral encephalitis in Western countries and acyclovir-treated patients often suffer from severe neurological sequels.
The pathogenesis of HSE remained unknown until the recent discoveries of Mendelian single-gene mutations specifically impairing immunity to HSV-1 at lea…
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