CORDIS Project
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This project develops a new method called High Resolution Relaxometry (HRR) to study nanosecond motions in DNA, focusing on how single strand breaks affect DNA dynamics and recognition by the PARP-1 protein, which is important for cancer treatment.
What role do conformational dynamics play in DNA function and repair?
Structures of DNA show local dynamics, conformational flexibility of bases, and large conformational changes in the double helix, indicating easily accessible motions.
Yet studying fast motions in nucleic acids is challenging.
To address this we will introduce High Resolution Relaxometry (HRR) and apply it to study single strand breaks (SSBs) in DNA.
Nucleic acids are often studied at atomic resolution with X-ray crystallogra…
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