CORDIS Project
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This project focuses on correcting genetic mutations causing long QT syndrome using patient-specific stem cells. It aims to create models for studying cardiac arrhythmias and drug responses, enhancing understanding of the disease's molecular mechanisms.
The long QT syndrome (LQTS) is an inherited or acquired disorder characterized by delayed ventricular repolarization predisposing affected individuals to fatal cardiac arrhythmias.
In ~90% of the familial cases, LQTS is associated with mutation in two potassium voltage-gated channel genes:
KCNQ1, causing LQT1, and KCNH2, causing LQT2.
Since the first report of human induced pluripotent stem cells (hiPSC), lines have been obtained from patients with both genetic and sporadic diseases. LQT1- and L…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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