CORDIS Project
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This research focuses on the mechanisms of DNA proofreading during replication, specifically how DNA polymerases detect and correct errors. By using advanced single-molecule techniques, it aims to enhance understanding of DNA replication fidelity and its implications for diseases like cancer.
DNA polymerases (DNA Pols) make various decisions during DNA replication.
Decisions regarding nucleotide selection, lesion bypass and how to respond to replication errors are a few important examples.
During replication, DNA Pols can synthesize DNA at remarkable rates, e.g. 1,000 bp/s for E.
Coli DNA Pol III.
However, errors can be introduced during replication, resulting in a terminal DNA mismatch.
Mismatches can then be sensed and removed by action of the 3’ to 5’ exonuclease activity of t…
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