CORDIS Project
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This project investigates the genetic factors influencing Chlamydia trachomatis infections and their role in fallopian tube pathology. Using organoid models and advanced gene-editing techniques, it aims to elucidate the mechanisms behind these infections and improve diagnostic methods for affected women.
Roughly 15% of couples trying to conceive suffer from subfertility.
One of its leading causes is developed pathology in woman’s fallopian tubes (tubal pathology or TP).
Persistent infection with Chlamydia trachomatis (CT) is the single most common cause of TP.
Women with a certain genetic makeup are more likely to develop TP after CT infection. I have so far identified 8 host genes and 13 genetic variants associated with CT infection and TP.
Their exact function is, however, not yet elucidated.…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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