CORDIS Project
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This project aims to characterize the interactions between the Human Immunodeficiency Virus type 1 (HIV-1) and human immune defenses, particularly focusing on retroviral restriction factors. Understanding these interactions will help develop new therapeutic strategies for HIV treatment and enhance knowledge about other…
The efficient replication and spread of the Human Immunodeficiency Virus type 1 (HIV-1), the causative agent of the AIDS pandemic, requires that it parasitize an array of cellular proteins, many of which are unknown or uncharacterized, to facilitate its replication.
In addition the virus must also defeat or subvert the human immune defences arrayed against it.
Some of these immune defences, the innate retroviral restriction factors, have the capacity not only to directly interfere with the repli…
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