CORDIS Project
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hOssicle focuses on creating miniaturized human bone models in mice to study blood disorders and improve drug testing. By engineering human-like bone structures, the project aims to better understand hematopoiesis and personalize treatment approaches for blood-related diseases.
hOssicle aims at developing miniaturized human bone organs in mice to be used as advanced model of healthy and malignant human hematopoiesis.
In Europe, 80 million people are estimated to suffer from blood disorders.
When at all existing, treatments are poorly effective: 92 % of new drugs successful in preclinical testing (animals and in vitro culture systems) fail in clinical trials.
This urgently calls for the development of superior models, to refine our understanding of human hematopoiesis a…
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