CORDIS Project
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This research explores how mutations in proteins that self-assemble into symmetrical complexes can lead to aggregation, a process linked to various diseases. By combining computational and experimental methods, the project aims to identify mutation hotspots and their effects on protein behavior.
In the protein universe, 30 to 50% of proteins self-assemble to form symmetrical complexes consisting of multiple copies of themselves, called homomers. A peculiarity of homomers is that any mutation is necessarily repeated in all subunits.
In a symmetric dimer for example, any mutation of one copy is also found in the second identical copy.
Depending where the mutation occurs on the surface, the repetitions of the mutation may or may not be “synergistic”, i.e., participate together to the forma…
WEIZMANN INSTITUTE OF SCIENCE
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