CORDIS Project
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This project explores the mechanisms of DNA double-strand break repair through homologous recombination in cells. It aims to understand how chromatin properties and chromosome movements influence this process, with potential applications in gene editing and yeast evolution.
DNA double-strand breaks (DSB) repair by homologous recombination (HR) entails identification of an intact homologous template DNA molecule in the genome.
Homology search is guided by the DSB-flanking ssDNA sequence assembled into a RecA-family nucleoprotein filament (NPF). A biased version of this process, regulated in an ill-defined manner by chromosomes’ structure and meiosis-specific HR proteins, also underlies homolog recognition and recombination during meiosis I in most examined eukaryote…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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