CORDIS Project
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This project investigates how neurons in the Drosophila brain maintain a balance between excitation and inhibition, which is crucial for normal brain function. By studying Kenyon cells, the project aims to uncover the molecular mechanisms that allow neurons to adapt to changes in activity levels, potentially informing…
Balanced excitation and inhibition is a fundamental principle of neural circuit function, and perturbed excitation/inhibition (E/I) balance has been linked to diseases such as epilepsy, autism and schizophrenia.
Maintaining E/I balance within normal bounds depends in part on homeostatic plasticity, in which neurons compensate for deviations in activity levels by adjusting their responsiveness to excitation and inhibition.
Yet despite recent progress in elucidating molecular mechanisms underlying…
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