CORDIS Project
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HOLOSTED is a biophysics project that combines advanced optical techniques to investigate the impact of Alzheimer’s disease on synaptic plasticity. It focuses on enhancing super-resolution microscopy methods and studying the role of Amyloid beta in neuronal signaling at the level of individual dendritic spines.
New perspectives are opening in neuroscience: the era of electricity is transitioning into the era of light.
Super-resolution microscopy was elected “Method of the year 2008” and optogenetics “Method of the year 2010” by the Journal Nature Methods.HOLOSTED is a biophysics project using these modern optical methods to study the effects of Alzheimer’s disease (AD) on synaptic plasticity.
It has two general objectives:
First, improving optical methods, including STED (STimulated Emission Depletion)…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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