CORDIS Project
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This project investigates the molecular mechanisms of homologous recombination, a DNA repair process that fixes double-stranded breaks. It focuses on the roles of the BTR complex in resolving DNA structures, using advanced imaging techniques to understand genome maintenance.
The project outlined here investigates the molecular mechanisms of the critical final steps of homologous recombination (HR) based DNA repair, a pathway that supports the error-free repair of double-stranded DNA breaks (DSBs).
In HR, the broken DNA ends are processed and homologous DNA provides a template for repair.
Engagement of both processed ends leads to the formation of a double Holliday-junction (DHJ) structure. DHJ can be resolved by enzymatic cleavage or dissolved by the concerted actio…
EOTVOS LORAND TUDOMANYEGYETEM
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