CORDIS Project
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This project investigates how the HIV-1 virus interacts with immune cells, particularly macrophages. By manipulating HIV-1 proteins, the project aims to activate antiviral responses that could lead to new treatment strategies against HIV-1 infection.
Our aim is to seek detailed molecular level understanding of the interactions between HIV-1 and innate immune sensors expressed in myeloid cells.
We have demonstrated that HIV-1 replicates in primary human macrophages without triggering interferon production.
However, by specific mutation of HIV-1 proteins or by manipulating interaction with host cofactors we can reveal the virus to innate immune receptors and activate an antiviral response leading to secretion of soluble type 1 interferon and c…
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