CORDIS Project
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The HIT-GLIO project aims to understand the interactions between pediatric high-grade gliomas and the immune system to identify new treatment targets. By utilizing advanced technologies and developing innovative models, the project seeks to enhance the effectiveness of existing therapies and improve patient outcomes.
Paediatric high-grade gliomas (pHGGs) are malignant, deadly tumours developing in infants and children.
Mutations in histone coding genes disturb epigenetic regulation and in cooperation with other oncogenes promote tumour initiation and progression. pHGGs are fast-growing and diffusive which makes them hard to remove or treat.
Surgery (unattainable in midline brain regions) and radiotherapy (RT) remain the only option with transient benefits as median survival is 9-15 months.
Those tumours are…
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
INSTYTUT POMNIK CENTRUM ZDROWIA DZIECKA
Poland, Warszawa
Type: Research institute
Activity type: Research Organisations
SME: No
France, Villejuif
Type: Research institute
Activity type: Research Organisations
SME: No
Stichting Sanquin Bloedvoorziening
Netherlands, Amsterdam
Type: Research institute
Activity type: Research Organisations
SME: No
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