CORDIS Project
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This project investigates the role of histone H1 in regulating antigenic variation in the Trypanosoma brucei parasite, which causes African sleeping sickness. It aims to understand how chromatin structure influences the parasite's immune evasion mechanisms.
Trypanosoma brucei is a unicellular parasite that causes African sleeping sickness, a fatal disease in humans.
There is no vaccine and drugs are very scarce and toxic. T. brucei evades the host immune system by periodically changing its dense, uniform coat of variant surface glycoproteins (VSGs), a mechanism knows as antigenic variation.
There are hundreds of VSG genes in the genome, but only one is transcriptionally active at a time. I recently observed major structural differences between the…
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
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