CORDIS Project
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This project explores the regulation of the Hippo pathway, a key tumor suppressor mechanism, by nutrient levels. It aims to uncover how nutrient sensing influences cancer development and potential therapeutic targets.
The Hippo pathway is a highly conserved tumour suppressor pathway that restricts cell proliferation and promotes apoptosis.
Although initially discovered in Drosophila, the Hippo pathway is highly conserved in mammals.
Mutations and epigenetic silencing of Hippo pathway genes are frequently found in cancer tissues.
Thus, our understanding of pathway regulation is important for the understanding of tumour formation and potential cancer treatments.The upstream regulation of the Hippo pathway is co…
CANCER RESEARCH UK LBG
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