CORDIS Project
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This project investigates how different types of pyramidal cells and interneurons in the hippocampus influence cognitive functions like spatial navigation, learning, and memory. Using advanced techniques, it aims to understand their roles in information processing and network dynamics in freely-moving rodents.
Neuronal activity of pyramidal cells in the CA1 area of the hippocampus enables spatial navigation, learning and memory and their firing is tightly controlled by GABAergic interneurons.
Both, pyramidal cells and interneurons are highly heterogeneous cell types.
Different CA1 pyramidal cells project to distinct brain areas including the subiculum, entorhinal, retrosplenial, prefrontal cortex, olfactory bulb, striatum and/or hypothalamus.
Distinct classes of interneurons innervate different subcel…
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