CORDIS Project
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This project focuses on understanding the structure of nuclear pore complexes in eukaryotic cells. By employing advanced imaging techniques like cryo-electron tomography and focused ion beam milling, it aims to achieve high-resolution maps that reveal the arrangement of proteins involved in nuclear transport.
In eukaryotes, nuclear pore complexes (NPCs) are large assemblies that selectively transport cargoes across the nuclear envelope.
Determination of the architecture of the NPC in molecular detail is central to understanding nuclear transport.
Structural analysis of the NPC is a major challenge given its sheer size and its dynamic nature.
Cryo-electron tomography (cryo-ET) has successfully been used to elucidate the overall architecture of the NPC, but substantial improvements in resolution are ne…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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