CORDIS Project
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This project investigates the role of hypoxia-inducible factors in leukemia initiating cells of acute myeloid leukemia. By studying gene expression in these cells, the research aims to identify mechanisms of chemotherapy resistance and potential therapeutic targets for improved treatment strategies.
Acute myeloid leukemia (AML) is a heterogeneous group of diseases caused by acquired cytogenetic and molecular alterations in hematopoietic progenitor cells.
There is a substantial need to develop new therapeutic approaches to AML; however, the genetic heterogeneity of AML constitutes a barrier for the development of targeted therapies.
Leukemia relapse after treatment is most often caused by a subgroup of cells commonly referred to as leukemia initiating cells (LICs), which are resistant to che…
INSTITUT JOSEP CARRERAS - CERCA
FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS
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