CORDIS Project
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This project investigates the role of proline isomerization in the transcription process of RNA polymerase II, focusing on how this affects gene expression. By utilizing advanced techniques to manipulate proline states, the research aims to uncover the implications of these changes on RNA processing and their potential…
Prolines are unique amongst aminoacids given that they naturally exist in two isomeric states:
CIS and TRANS.
The transition between these states is slow but can be catalyzed by the activity of proline isomerases such as PIN1.
Recent in vitro work suggests that PIN1 can alter the phosphorylation dynamics of the C-terminal domain (CTD) of RNA polymerase II (Pol II) by inhibiting phosphatase recognition.
Given Pol II is solely responsible for transcribing all protein-coding genes and that CTD phos…
KOBENHAVNS UNIVERSITET
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