CORDIS Project
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This project investigates how maternal microbiota influences the development of immunity and metabolism in newborns. It aims to uncover the molecular mechanisms behind maternal microbial effects during critical early life stages, potentially impacting health outcomes later in life.
BackgroundHumans and other animals harbour enormous microbial consortia, especially in the lower intestine.
My group has now shown that effects of the microbiota on host are far earlier and more pervasive than previously appreciated, starting even before birth from exposure to defined maternal microbial metabolites.ConceptThere is a critical window for development of immunity and metabolism in early life.
This shapes infectious resistance, lymphocyte repertoire development and the likelihood of…
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