CORDIS Project
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This research investigates how small RNAs regulate the transfer of antibiotic resistance in bacteria. By studying the interactions of RNA molecules and their chaperones, the project aims to uncover mechanisms that could potentially inhibit the spread of resistance genes.
In bacteria, DNA transposons play a key role in transferring antibiotic resistance, which poses a major threat to human health. I want to understand how this transfer can be controlled.
One of the regulatory pathways applied in vivo uses specific small RNAs (sRNAs) controlling translation of the transposase mRNA.
This is achieved using the general bacterial RNA regulatory machinery, and is mediated by the small RNA chaperone, HFQ. HFQ is a highly conserved, SM-like protein that modifies the seco…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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