CORDIS Project
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This project investigates the enzyme flap endonuclease 1 (FEN1), which is crucial for DNA replication and repair. It aims to understand how FEN1 recognizes and processes DNA structures, using advanced techniques like nuclear magnetic resonance to explore enzyme-substrate interactions.
Flap endonuclease 1 (FEN1) catalyzes the removal of 5’-flap structures generated by strand-displacement synthesis during lagging-strand DNA synthesis and long-patch base excision repair.
Homozygous knockout of FEN1 in mice is embryonically lethal, whereas haploinsufficiency or catalytic deficiency due to mutation leads to rapid tumor progression, thereby illustrating the importance of FEN1 to genome stability.
Despite its critical role in DNA replication and repair, a detailed mechanistic unders…
THE UNIVERSITY OF SHEFFIELD
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