CORDIS Project
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This project investigates how cells repair DNA damage in heterochromatin, a densely packed region of the genome. By using advanced experimental systems, the research aims to uncover the unique mechanisms involved in maintaining genome stability and tissue health, which could have implications for understanding diseases…
Cells face continuous challenges from insults that damage their DNA.
To safeguard DNA integrity, a range of repair mechanisms have evolved, which are crucial for organismal survival.
However, the eukaryotic nucleus contains different chromatin domains, each requiring specific repair mechanisms to ensure genome stability.
In particular, the compact and transcriptionally silenced heterochromatin domains, which are riddled with repetitive DNA and developmental genes, are a challenging environment t…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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