CORDIS Project
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This project investigates the heterogeneity of Lewy Bodies in Parkinson's Disease at a single-cell level using advanced imaging and proteomics techniques. The goal is to identify protein variations that influence disease progression and potential therapeutic targets.
Parkinson’s Disease (PD) is the second most common neurodegenerative disease affecting millions world-wide. PD pathophysiology is associated with protein aggregates called Lewy Bodies (LBs), and aggregation is impacted by cellular environment, post-translational modifications and genetic predispositions.
Heterogeneity in the composition of LBs across the brain has consequences for neuronal cytotoxicity and although LBs are a main focus in PD research, only a limited number of projects have explo…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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