CORDIS Project
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This project investigates the role of cardiac myosin light chain kinase in enhancing the maturity of stem cell-derived heart cells for better drug testing and potential heart disease treatments. It aims to improve the functionality of these cells for use in toxicology and transplantation applications.
The main hurdle to the effective use of stem cell derived cardiomyocytes (hESC-CMs and hIPSC-CMs) in drug toxicology screening and transplantation therapy is their embryonic nature.
It is recognised that hESC-CM and hIPSC-CM are immature and undergo limited maturation in the laboratory.
This creates problems as the cells may not display appropriate responses to target drugs in toxicology screening and may not be suitable for transplantation into the damaged heart.
The research outlined in this p…
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United Kingdom, Nottingham
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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