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The HerQuLes project investigates how specific transcription factors regulate the quiescence of stem cells, focusing on chromatin organization in this state. Using the nematode Caenorhabditis elegans as a model, the project aims to understand the mechanisms that maintain cellular quiescence, which is crucial for tissue…
Stem cell pools in our body regulate tissue differentiation in development and remain available during our lifetime for tissue regeneration.
These cells exsit in a cell cycle arrested but metabolically active state known as quiescence.
Understanding how these cells maintain quiescence and survive over years is fundamental, as its dysregulation impairs regenerative capacity and is linked to ageing, cancer, and degenerative diseases.The HerQuLes project aims to uncover the mechanisms by which key…
UNIVERSIDAD DE SEVILLA
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