CORDIS Project
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This project aims to establish the role of the RSK2 gene as a tumor suppressor in liver cancer. It will utilize advanced genetic techniques to model the effects of RSK2 mutations and their impact on cancer development.
Hepatocellular carcinoma (HCC) ranks third in cancer mortality worldwide.
In spite of this, effective treatment options are limited, partly due to a poor understanding of the molecular basis of HCC, which hampers development of targeted therapies.
Recently, cancer genome sequencing mapped the landscape of genetic aberrations in HCC and unexpectedly revealed the kinase RSK2 as the most frequently mutated gene in the RAS-RAF-ERK pathway. I hypothesize that RSK2 is a tumor suppressor in HCC by acti…
KOBENHAVNS UNIVERSITET
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