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The Heparanib Proof-of-Concept project aims to evaluate small molecule inhibitors for treating metastatic cancers. It focuses on synthesizing clinical-grade materials and conducting pharmacokinetic studies to support the development of a new cancer therapy.
The Heparanib Proof-of-Concept project aims to establish the feasibility of our unique small molecule heparanase inhibitors as drug candidates for the treatment of metastatic cancers.
To strengthen our science case (experimental development A) and by building on our in vivo data in mouse models for metastatic breast cancer, lung cancer and multiple myeloma, we will (A-I) design a suitable route of synthesis to prepare sufficient quantities of clinical grade material; (A-II) synthesise reference…
UNIVERSITEIT LEIDEN
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