CORDIS Project
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This project focuses on RNA base editing using ADAR enzymes to correct genetic mutations and address chronic liver disease. By developing a platform for targeted RNA editing, it aims to modulate protein function and improve liver health through innovative therapeutic approaches.
RNA base editing, catalyzed by ADAR enzymes, is a natural process that diversifies protein function by modifying mRNA.
Redirecting ADAR activity with RNA-based drugs holds significant promise for correcting genetic mutations and uniquely enables precise modulation of protein function.
However, major challenges remain to fully unlock this potential.In this collaborative effort, we present a target discovery platform and demonstrate in vivo proof-of-concept (PoC) that targeted RNA base editing can…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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Israel, Ramat Gan
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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