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HEDGE-A aims to enhance the production of recombinant adeno-associated viruses for gene therapy by utilizing big data and synthetic biology. The project focuses on developing scalable bioprocesses and cell platforms to reduce costs and improve accessibility to gene therapies.
HEDGE-A will address one of the current main challenges of biopharmaceutical production:
The scalability of the recombinant adeno-associated virus (rAAV) production process.
Big Data approaches like transcriptomic and proteomic analyses will be used together with synthetic biology tools to engineer cell cultures and improve rAAV production.
The objectives of HEDGE-A are to design (1) a suitable cell platform to sustain transfection at high cell densities and (2) a scalable upstream bioprocess to…
TECHNICAL UNIVERSITY OF DENMARK DTU
DANMARKS TEKNISKE UNIVERSITET
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