CORDIS Project
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This project investigates the role of autophagy in maintaining synaptic function, particularly during aging and neurodegenerative diseases. Using Drosophila models, it aims to understand how enhancing autophagy can support neuronal health and potentially mitigate age-related cognitive decline.
The deterioration of brain function and prevalence of dementias are some of the most striking and unfortunate consequences of ageing.
Proper neuronal function relies on accurate signal transmission via synapses.
While the basic cell biology of synaptic transmission is well studied, how precise activity is maintained over time remains poorly understood.
Several age-dependent neurodegenerative conditions, characterized by the build-up of protein aggregates, affect synaptic function.
These observat…
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