CORDIS Project
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This project investigates the relationship between ganglioside metabolism and white matter abnormalities in Huntington's disease. It aims to understand how decreased levels of GM1 gangliosides affect brain function and could provide insights into potential therapeutic approaches for this neurodegenerative disorder.
Huntington’s disease (HD) is a neurodegenerative disorder caused by expansion of a CAG repeat, within the gene encoding huntingtin (Htt) and characterized by the progressive neurodegeneration and associated motor, cognitive and behavioral disturbances.
Mutant Htt exerts adverse effects in neurons and non-neuronal cells.
Animal studies describe white matter segmentation and myelin breakdown in HD.
These evidences recapitulate the brain white matter volume loss described in pre-symptomatic and sym…
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