CORDIS Project
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This project develops haploid embryonic stem cells from mammals, enabling genetic analyses that were previously limited to haploid organisms. It aims to facilitate the discovery of essential genes and improve understanding of various biological processes and diseases through innovative genetic screening techniques.
Some organisms such as yeast or social insects are haploid, i.e. they carry a single set of chromosomes.
Organisms with a single copy of their genome provide a basis for genetic analyses where any recessive mutation of essential genes will show a clear phenotype due to the absence of a second gene copy.
Recessive genetic screens have markedly contributed to our understanding of normal development, basic physiology, and disease.
However, all somatic mammalian cells carry two copies of chromosomes…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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