CORDIS Project
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This project investigates the heparin-binding haemagglutinin adhesin (HBHA) protein from Mycobacterium tuberculosis, which plays a key role in tuberculosis spread. The goal is to understand its structure and function using advanced nuclear magnetic resonance techniques.
Tuberculosis (TB) is one of the most aberrant causes of global mortality and the molecular mechanisms of its pathogenesis are not well understood.
The extrapulmonary dissemination of TB involves requires a crucial virulence factor designated as heparin-binding haemaglutinin adhesin (HBHA). HBHA is a 28 kDa dimeric protein localised at the surface of the Mycobacterium tuberculosis (MTB) that binds dextran sulphate, dermatan sulphate, glycosaminoglycans and heparan-sulphate proteoglycans thus med…
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
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