CORDIS Project
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This project investigates how genetic variants in the FKBP5 gene interact with early trauma to increase the risk of depression and anxiety disorders. It aims to understand the molecular mechanisms behind these interactions and their implications for potential treatments.
Exposure to traumatic experiences as well as chronic stress has been shown to increase the risk for a number of psychiatric disorders including major depression and anxiety disorders by inducing longterm alterations in the reactivity of the stress hormone system.
These effects can be moderated by genetic variants, one of them being functional polymorphisms in glucocorticoid receptor (GR) co-chaperone gene FKBP5.
Preliminary studies in my laboratory suggest that this GxE interaction is mediated b…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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